Active Ingredients: Azithromycin
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Obtaining arterial tissue is also very problematic. It would be logistically impossible to obtain tissue from thousands of subjects with coronary disease, even if it were surgically feasible.
Histologic assessments of the target tissue are therefore not possible.
Recently, there has been progress in examining tissue by PCR, including circulating white blood cells, as a surrogate for active infection with C. While this procedure still needs to be validated and a clinical correlation confirmed, it holds promise as a future method for selecting patients.
For the moment, selection of patients will be limited to clinical criteria surrounding the underlying disease.
A number of antibiotics, including macrolides, tetracyclines, and quinolones, have in vitro activity against C.