Active Ingredients: Azithromycin
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Random testing of urine samples at delivery established a point-prevalence for chloroquine use. Parasitological evidence of chloroquine efficacy was reported, as well, in a recent four-arm clinical trial conducted in Ghana among pregnant women with asexual P falciparum stage parasitaemia.
Potential for azithromycin and chloroquine when used in combination for the prevention of malaria Evidence for synergy of the combination in vitro An additive effect between azithromycin and chloroquine has been shown in sensitivity testing conducted over a 48-hour period.
When incubation is extended to 68 hours, drug synergy has been seen against chloroquine-resistant isolates; the combination remains additive, however, against chloroquine-sensitive parasites.
Sidhu et al in contrast, observed an additive effect at 96 hours of incubation against chloroquine-resistant isolates.
Azithromycin and chloroquine do not exhibit any clinically relevant pharmacokinetic interactions, although chloroquine resistance is reversible with calcium channel blockers, such as verapamil and desipramine, that inhibit p-glycoprotein-mediated efflux.