Active Ingredients: Azithromycin
The three components are combined in a specific ratio to prolong the release of amoxicillin from Moxatag compared to immediate-release amoxicillin.
The mean plasma concentration-time curve is shown below in. Figure 1.
Amoxicillin diffuses readily into most body tissues and fluids, with the exception of brain and spinal fluid, except when meninges are inflamed. Amoxicillin is primarily cleared by renal excretion. Probenecid decreases the renal tubular secretion of amoxicillin.
Microbiology Mechanism of Action Amoxicillin is similar to penicillin in its bacterial action against susceptible organisms during the stage of active multiplication. It acts through the inhibition of cell wall biosynthesis that leads to the death of the bacteria.
Mechanism of Resistance To date there are no known mechanisms of resistance to penicillin or amoxicillin in Streptococcus pyogenes.
Moxatag has been shown to be active in vitro against isolates of the microorganism S. Gram-Positive Bacteria: Streptococcus pyogenes The following in vitro data are available, but their clinical significance is unknown.
Gram-Positive Bacteria: Streptococcus spp. Group B, and G; Beta-hemolytic Susceptibility Test Methods: When available, the clinical microbiology laboratory should provide cumulative in vitro susceptibility test results for antimicrobial drugs used in local hospitals and practice areas to the physician as periodic reports that describe the susceptibility profile of nosocomial and community-acquired pathogens.
These reports should aid the physician in selecting the most effective antimicrobial. These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds.
The MICs should be determined using a standardized method broth or agar 1,2. An organism that is susceptible to penicillin can be considered susceptible to amoxicillin when used for approved indications 2.
It is characterised by recurrent episodes of flushing, erythema redness, papules pimples, pustules and telangiectasia permanent distended blood capillary vessels with a spidery appearance Elewski; Korting; Marks; Powell.
Although there is no standard clinical definition of the condition, rosacea is generally classified into four subtypes and one variant Wilkin; Wilkin. Subtype 1: erythematotelangiectatic rosacea, where the clinical features include flushing and persistent central facial erythema redness with or without telangiectasia.
Subtype 2: papulopustular rosacea, characterised by persistent central facial erythema with transient, central face papules or pustules, or both.