Active Ingredients: Azithromycin
Solithromycin is in clinical development for treatment of community-acquired bacterial pneumonias, but there are also some data on its activity against urogenital pathogens.
An in vitro study that included 5 macrolide-susceptible clinical isolates of M. Another in vitro study included a collection of 40 genetically and geographically diverse M. There were 25 macrolide-susceptible isolates and 15 high-level macrolide-resistant isolates, 5 of which were also resistant to fluoroquinolones.
The investigators found that solithromycin MICs for macrolide-susceptible M. These data demonstrate that while solithromycin MICs were several dilutions lower than those of azithromycin for macrolide-resistant isolates, some cross-resistance was still evident.
A theoretical advantage of solithromycin for treatment of M. In vitro studies have also shown that solithromycin is active against Chlamydia trachomatis and N.
Limited data for the in vivo efficacy of solithromycin in treatment of sexually transmitted infections have been reported.
Hook et al conducted a phase 2 trial of 1200-mg and 1000-mg oral doses of solithromycin for treatment of uncomplicated gonorrhea. Following therapy, cultures for N.
Clearance of M. In, however, concerns regarding potential hepatotoxicity were raised and solithromycin did not receive FDA approval in the United States.
Further clinical trials will be needed to establish safety before it will be able to be evaluated for use in the STI field. Nafithromycin WCK 4873 Wockhardt Ltd is a second-generation ketolide that is also undergoing clinical trials for community-acquired bacterial pneumonias that has activity against M.
However, MICs for 2 macrolide-resistant strains of M.
Because the macrolide resistance mechanisms for M. Although both macrolides and pleuromutilins bind the 50 S ribosome, their molecular mechanism of action differs, so there is limited cross-resistance between the 2 classes.
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