Active Ingredients: Norfloxacin
Main results The groups did not differ for mortality although fewer deaths occurred in the norfloxacin group 4 vs 7 deaths.
Individual decisions and rights have monitored that the successful amount would let to construct the gradual marrow pigeonhole as possibly. If you are taking any other medicines.
This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines. If you have ever had an allergic reaction to a medicine.
How to take norfloxacin Before you start taking the tablets, read the manufacturer's printed information leaflet from inside the pack. Take norfloxacin exactly as your doctor tells you to. The usual dose is one 400 mg tablet, taken twice a day.
Swallow the tablet with a drink of water.
This is because your body absorbs less norfloxacin after a meal, which means the medicine is less effective. Try to space out the doses over the day - so ideally, take a dose every 12 hours. The first goal of therapy is the prevention and treatment of dehydration, which is of particular concern for young children, pregnant women and the elderly.
Commercial packets of oral rehydration salts are readily available in pharmacies and should be purchased before travel. The other element of TD self-treatment is to recommend travellers bring an antimotility agent plus an antibiotic with them.
When should loperamide alone versus loperamide plus an antibiotic be taken? For mild symptoms of watery diarrhoea, self-treatment with oral rehydration plus loperamide is recommended.
If TD is moderate or severe at onset, then combination therapy with loperamide plus antibiotics should be started immediately, as this optimises the clinical benefit of self-treatment by providing more rapid relief and shortening the symptom duration.
Despite warnings regarding the safety of antidiarrhoeal agents with bloody diarrhoea or diarrhoea accompanied by fever, the combination with antibiotics is likely to be safe in the setting of mild febrile dysentery,18 and a number of studies have shown the combination to be more efficacious than use of either agent alone.
The most commonly used antibiotics for empirical TD therapy are fluoroquinolones either norfloxacin or ciprofloxacin or azithromycin Table 1.
Cotrimoxazole has been used but is no longer recommended because of widespread resistance. For TD caused by ETEC, the fluoroquinolones and azithromycin have similar efficacy; however, in Asia particularly South and South-East Asia, Campylobacter is a common cause of TD and strains occurring in this part of the world show a high degree of resistance to fluoroquinolones.
Azithromycin remains generally efficacious despite emerging resistance, and is also the preferred treatment for diarrhoea with complications of dysentery or high fever, and for use in pregnant women or children under the age of 8 years, in whom avoidance of quinolones is preferred.
Table 1. In New Zealand, there are two tablets per pack, thereby more easily lending itself to a 1000 mg stat dose than a 500 mg daily dose for up to 3 days.
What is the optimal dosing schedule?