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Journal of Environmental and Public Health

Various in vitro and in vivo studies have established their antimicrobial spectrum against clinically significant Gram-positive, Gram-negative, atypical, and anaerobic pathogens.

As bacterial etiologies are the most common causative agents of TD, the use of antibiotic prophylaxis to prevent TD has been reported among travelers for several years. The use of antibiotic prophylaxis for TD prevention in travelers is still controversial, mainly because of difficulties balancing the risks and benefits.

Many factors, such as emerging drug resistance, side effects, cost and risk behavior need to be considered.

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This article aims to review antibiotic prophylaxis from the 1950 s to s, to describe the trend and reasons for different antibiotic use in each decade.

We conclude that prophylactic antibiotics should be restricted to some high-risk travelers or short-term critical trips.

Introduction International travel is rapidly increasing, with 1.

Zargarzadeh et al.
Signed threat copies of this Agreement, and attachments will certainly bind the parties to the same time as original documents.

Most TD usually results in mild symptoms and is self-limiting, however clinical symptoms can be severe and cause several issues, including disruption to travel, or long-term effects and hospitalization.

In addition, ETEC has been documented as the most common pathogen in travelers returning from African countries. Interestingly, Campylobacter is the most common pathogen isolated from travelers returning from Southeast Asia. Increasing reports of norovirus in travelers returning from multiple regions of the world are of concern, as it is an important cause of TD.

Travelers to remote areas far from medical facilities are often advised to take antibiotics when symptoms of TD develop. In contrast, some high-risk groups, such as immunocompromised travelers, might prefer to take antibiotics prophylactically to prevent TD.

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Supplementary Materials References K. Holloway and L.

As bacterial etiologies are the most TD prevention in travelers is still controversial, mainly because of difficulties balancing the risks and benefits for several years. The use of antibiotic prophylaxis for resistance, side effects, cost and risk behavior need to be considered.

View at: Google Scholar T. Atinafu. Takele.


Kassie et al. View at: Google Scholar A. Law. Sakharkar. Zargarzadeh et al.

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