Active Ingredients: Gabapentin
It is not bound to plasma proteins 124 and has a volume of distribution of 0. Gabapentin is generally well tolerated with a favourable side-effect profile. When the safety and tolerability of gabapentin were evaluated 63 in 2216 patients undergoing seizure treatment, reported adverse effects were somnolence 15.
Similar side-effects were observed in patients with chronic pain treated with gabapentin.
Gabapentin has been shown to inhibit the evoked release of glutamate, 15 aspartate, 31 substance P, and calcitonin gene-related peptide CGRP 30 from the spinal cord of rats. Therefore, multimodal analgesic techniques utilizing a number of drugs acting on different analgesic mechanisms are becoming increasingly popular.
Three outcome measures postoperative opioid requirements, pain score at rest, and pain score during activity were compared between gabapentin and placebo groups. Gabapentin significantly reduced postoperative opioid requirement during the first 24 h in six of the seven studies.
CMAJ; 190 26: E 786-793.
Pregabalin and gabapentin become controlled drugs to cut deaths from misuse. BMJ; 363: k 4364.
Summary safety review — Gabapentin — Assessing the potential risk of serious breathing problems. Gabapentin Neurontin: risk of severe respiratory depression.
Gabapentin for pain: New evidence from hidden data. Therapeutics Letter. Therapeutics Letter. Expect analgesic failure; pursue analgesic success. BMJ; 346: f 2690.