Active Ingredients: Gabapentin
Disulfiram is a second-line agent that works by causing unpleasant physiologic reactions eg, vomiting, sweating, headaches when alcohol is consumed, thereby deterring motivation to drink.
For years, benzodiazepines have been the gold standard treatment for alcohol withdrawal due to their well-documented efficacy. Recent study results suggest gabapentin is safe and effective for AUD treatment.
In preclinical studies, gabapentin was shown to normalize stress-induced GABA activation in the amygdala associated with alcohol dependence.
This mechanism provided the rational for its use in alcohol dependence. One trial conducted in an outpatient treatment center examined the efficacy of 28-day gabapentin treatment in reducing alcohol consumption and craving.
Eligible subjects were randomized to placebo or gabapentin 300 mg twice-daily. Mean percentage of heavy drinking days and abstinence days were statistically significant in favor of the gabapentin group.
Mild adverse events included insomnia or sleepiness, while study limitations included small sample size and use of diazepam with gabapentin prior to and during the treatment phase.
It also evaluated number of drinks and number of heavy drinking days per week. Alcohol use, cravings, mood, sleep, and medication safety were assessed during weekly visits.
Gabapentin had a significant linear dose effect on complete abstinence rate and no days of heavy drinking. Following discharge, patients will take gabapentin as directed by their discharge instructions, and in the process track their opioid consumption on their own in their diaries.
They will also document their pain, nausea and satisfaction levels according to the visual analogue scale VAS. At the first post-operative appointment, patients' levels of opioid use will be verified and compared to the amount recorded in each diary; the actual number of tablets consumed will be compared with the documented amounts and with the prescriptions they received.
Patients receiving a new prescription will also receive a matching diary for the total length of opioid treatment, including further directions on how to wean themselves off their medications.
Outcome measures will be collected at both post-operative visits, the first occurring 8-10 days after surgery and the second 2-3 months following. Additional data including length of stay, postoperative complications including infection and readmission, Emergency Department visits, and routinely collected postoperative functional outcome measures PROMs will be recorded.
The Principal Investigator PI will review all drug consumption data and patient-reported outcome measures with the research assistant RA on a monthly basis as it is collected.
Warnings for other groups For pregnant women: The use of gabapentin has not been studied in humans during pregnancy.
Research in animals has shown negative effects to the fetus when the mother takes the drug. Before you don't tossing with the object-oriented domain chance of bacterial breast cancer MRCA of living online in yours variant.
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