Active Ingredients: Gabapentin
Keywords: Postherpetic neuralgia, Gabapentin, Herpes zoster, Prevention, Primary health care Background Herpes zoster HZ, often called shingles, is a common disease characterized by a painful, unilateral vesicular eruption that is caused by reactivation of a dormant varicella zoster virus within the dorsal root or cranial nerve ganglia.
The most frequent complication following an acute episode of HZ infection is postherpetic neuralgia PHN, a chronic and debilitating neuropathic pain syndrome that is refractory to most therapeutic strategies. The symptoms associated with PHN are sleep disturbances, mood changes, depression, and anxiety.
The development of PHN is associated with increased patient age and severity of acute pain. Abstract Background Postherpetic neuralgia PHN is a chronic neuropathic pain that results from alterations of the peripheral nervous system in areas affected by the herpes zoster virus.
The symptoms include pain, paresthesia, dysesthesia, hyperalgesia, and allodynia. Despite the availability of pharmacological treatments to control these symptoms, no treatments are available to control the underlying pathophysiology responsible for this disabling condition.
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