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Secondary outcomes included measures of perceived stress, cognitive function, fatigue, and quality of life.
The groups were well matched on baseline characteristics.
All participants in the control group completed the study, while 4 MBI participants did not. Conclusions This pilot study demonstrates that an MBI improves coping, depression and perceived stress in newly diagnosed persons with RMS.
Whether this improvement is maintained over time still needs to be confirmed. The heterogeneity reflects the complex underlying neuropathology of this disease. For this reason, it is still unclear which MS-related brain pathology predominantly affect cognition and whether different cognitive domains are preferentially affected.
Objective This study investigated the differences in the relationship between performance decline in different cognitive domains in patients with relapsing-remitting multiple sclerosis RRMS and measures of structural and functional brain damage.
The relationship between cognitive performance of patients with RRMS and various MS-related symptoms and different indices of structural and functional alterations was also investigated.
Moreover, patients showed volumetric reductions in white matter WM, thalamus and parahippocampal gyrus, decreased brain stem FA, increased FC in the anterior default-mode network DMN and decreased FC in the posterior DMN and both fronto-parietal networks.
Attention performance was associated with both macro- and micro-structural WM damage and mainly driven by disease duration.
No significant associations were found between alterations in FC across brain networks and either cognitive or non-cognitive symptoms.
Conclusions This study shows that mild cognitive decline in attention abilities of patients with RRMS appears to be associated prominently with WM damage, while no relationship was detected between alterations in resting-state FC and cognitive performance.
Further studies are needed to clarify the differential impact of both structural and functional brain damage in patients with more severe impairment in different cognitive domains.
Patients completed an online survey including demographics, co-morbidities, a description of their most recent meal and the Stanford Sleepiness Score SSS.
Their siblings, partners and friends were asked to complete a similar survey. Ich versuche immer, aus dieser Intuition reagieren. Bis jemand sagte: Du gibst jemandem eine Chance, Sie sind voreingenommen.