Active Ingredients: Gabapentin
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Pain relief was sustained in two thirds during a mean follow-up time of 8 months.
The fact that gabapentin was well-tolerated and without serious side effects is an important advantage when prescribing for elderly patients. One case report describes a 67-year-old woman with a history of mood disorders and alcohol abuse receiving gabapentin following a diagnosis of polyneuritis.
She was taking at least 7,200 mg daily, twice the prescribed amount, and exhibiting aberrant drug-related behaviors, such as exaggerating symptoms to get prescriptions and asking pharmacies to give her gabapentin without a prescription.
When denied her prescription, she developed withdrawal symptoms including trembling, sweating, excitation, pallor, and exophthalmia and was hospitalized.
Taking a daily dose of 3,600 mg, one patient cited reduced alcohol cravings and feeling calmer. After stopping gabapentin, both patients experienced a similar tremulous, agitated, and tachycardic state. Despite treatment that included lorazepam, symptoms did not significantly improve until gabapentin was resumed.
The higher dose was most effective at achieving abstinence and symptom control. Gabapentin at both dosages was well-tolerated and no significant differences were noted between groups in type, number or severity of adverse events.
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