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    Doxycycline Oracea is used only to treat pimples and bumps caused by rosaceae a skin disease that causes redness, flushing, and pimples on the face. Vital signs were recorded and genital examination was performed, and participants had repeat testing for C.

    The primary analysis was performed on the primary efficacy variable using the modified intent-to-treat mITT population and making no imputations for nonevaluable outcomes.

    Because randomization was stratified by participant sex, a post hoc analysis was conducted to evaluate microbial cure rate differences by sex for each treatment group.

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    We performed a secondary efficacy analysis of microbial cure in all mITT participants regardless of evaluability, with missing outcomes considered treatment failures.

    Safety was assessed by summarizing AEs, withdrawals, vital signs, and clinical laboratory test results in the safety population, which included all randomized subjects taking at least 1 dose of the study drug.

    Ethical Approval Study sites received approval from a properly constituted institutional review board.

    Doxycycline inhibited SE-stimulated T-cell proliferation and production of cytokines and chemokines by human peripheral blood mononuclear cells.

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    These results suggest that the antibiotic doxycycline has anti-inflammatory effects and is therapeutically useful for mitigating the pathogenic effects of SE.

    These toxins are called superantigens because of their ability to polyclonally stimulate large populations of T cells 1, 7.

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  • Thus, staphylococcal exotoxins SE are potent activators of the immune system and cause a variety of diseases in humans, including food poisoning, toxic shock, and autoimmune diseases 1, 6, 12, 14.

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