Active Ingredients: Doxycycline
The mechanisms responsible for decreased absorption appear to be chelation and an increase in gastric pH.
Recent research has shown no significant loss of effectiveness in oral contraceptives while using most tetracycline antibiotics including doxycycline, although many physicians still recommend the use of barrier contraception for people taking the drug to prevent unwanted pregnancy.
Doxycycline crosses into breastmilk. The best available evidence indicates that doxycycline has little or no effect on hypoplasia of dental enamel or on staining of teeth and the CDC recommends the use of doxycycline for treatment of Q fever and also for tick-borne rickettsial diseases in young children and others advocate for its use in malaria.
It works by preventing bacteria from reproducing through the inhibition of protein synthesis. It can also be re-absorbed in the renal tubules and gastrointestinal tract due to its high lipophillicity so has a long elimination half life, and does not accumulate in the kidneys of patients with kidney failure due to the compensatory excretion in faeces.
It inhibits the synthesis of bacterial proteins by binding to the 30 S ribosomal subunit, which is only found in bacteria.
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There are also some common medicines you should not mix with it. Doxycycline can also be called by the brand name Vibramycin-D.
Who can and can't take doxycycline Doxycycline can be taken by adults and children over 12 years old. Doxycycline is not usually recommended in pregnancy or when breastfeeding.
It isn't suitable for some people. To make sure this medicine is safe for you, tell your doctor if you have: ever had an allergic reaction to doxycycline or any other medicine in the past kidney problems an inflamed food pipe oesophagitis lupus, an autoimmune disease myasthenia gravis, an illness that causes severe muscle wasting 4.
How and when to take it Your dose of doxycycline depends on why you are taking it.
The usual dose is 100 mg to 200 mg once or twice a day. If you're taking doxycycline more than once a day, try to space your doses evenly throughout the day.