Active Ingredients: Hydroxyzine
Bilastine is approved in several countries for the treatment of allergic rhinoconjunctivitis seasonal and perennial and urticaria.
It is a non-sedating and long-acting antihistamine, with selective H 1-receptor affinity, and no affinity for other aminergic receptors. In controlled clinical trials at the recommended therapeutic dose of 20 mg once daily, the CNS effects and safety profile of bilastine were similar to those of placebo; no significant difference in the incidence of drowsiness was noted between bilastine and placebo.
As is the case for fexofenadine, bilastine is also a P-glycoprotein substrate and its physicochemical properties can limit blood—brain barrier penetration. The current study is the first to assess brain H 1 RO by bilastine.
Methods Study design This was a phase I, double-blind, placebo-controlled, crossover study, in which subjects were randomized to one of six test-treatment sequences two subjects per sequence comprising the three test compounds.
A screening visit was conducted within 3 weeks before the first experimental session, and each subject participated in three sessions.
To allow for washout of bilastine and hydroxyzine, there was an interval of at least 1 week between sessions. At 3—7 days after completion of all three sessions, a final study visit was conducted which consisted of a physical examination, assessment of laboratory and urinary parameters and final safety evaluation.
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For this test, your doctor will thread a tiny ultrasound device through the catheter and into the artery. If surgical therapy is being contemplated, methylprednisolone 4 mg dosage newer techniques of functional endoscopic sinus surgery are performed to clear sinuses of chronic infection, inflammation, and polyps.
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