Active Ingredients: Hydroxyzine
If pneumonitis is confirmed, treatment includes high-dose systemic corticosteroids and discontinuation of the PI 3 K pathway inhibitor. The most commonly seen toxicities with the PI 3 K isoform-specific inhibitor, alpelisib, are hyperglycemia, rash, and diarrhea.
Toxicities can often lead to dose reductions, treatment delays, and treatment discontinuation if they are not successfully managed.
Fortunately, most toxicities are reversible with drug interruption, due to the short half-life of the drug, and manageable with early intervention and supportive medications.
Patients can be successfully treated with PI 3 K pathway inhibitors with a proactive and interdisciplinary approach that includes comprehensive education about the range of toxicities, frequent monitoring and early toxicity recognition, prophylactic measures when available, and active intervention with supportive care.
Funding This paper was published as part of a supplement funded by an educational grant from Novartis. SEN has declared no conflicts of interest.
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