Active Ingredients: Isotretinoin
We then sent the lists obtained from the pharmacies to the clinics that had received the clinic approval, and they provided infor- mation on personal identity number and on actual start- ing and stoppingdates of treatment as well as prescribed daily dose.
We did sensitivity analyses on the source of information individual application versus clinic approval about exposure.
It is not known whether the patient had other medical conditions that could have led to the curling of her hair.
The patient mentioned her hair started changing and falling out after approximately 6 months. It is unknown if the patient suffered from other medical conditions or used other drugs that could have played a part in the curling of her hair.
Although alopecia is described for many drugs, a change in hair texture causing the hair to curl or kink is less common. Although the hair of both patients had a curly appearance, there is a difference between kinked hair and curly hair. With kinking of the hair, the hair looks curly due to torsion and irregularities in hair structure.
Curling of the hair is the result of an oval hair shaft, which grows out of the scalp under an angle. The amount of disulfide bonds between the hair proteins and hair shaft give rise to a certain degree of curling of the hair.
Hair thinning can cause kinking of the hair; however, why this happens is unknown since factors determining different hair shapes are not completely understood. The inner root sheath IRS is an important structure of the lower part of the hair follicle that surrounds and protects the growing hair, and is essential for the proper molding, adherence, and keratinization of the growing hair.
With regard to retinoids, an influence on the keratinization of the IRS of the hair follicle during the anagenic growth phase has been proposed as a possible mechanism. These RXR receptors are speculated to play a role in new hair growth.
It is speculative whether the affected hairs have regrown in follicles from which hairs have previously been lost. Isotretinoin therapy for acne vulgaris: a re-evaluation of the need for measurements of plasma lipids and liver function tests.
Br J Dermatol 1993; 129: 704—707. Dermatology; 218: 178—180. Low dose isotretinoin combined with tretinoin is effective to correct abnormalities of acne.