Active Ingredients: Isotretinoin
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Treatment Isotretinoin 13-cis retinoic acid is an oral pharmaceutical drug primarily preferred in the treatment of severe nodular acne. The adverse effects are the flare of acne, cheilitis, xerosis, an increased susceptibility to sunburn, muscle aches, myalgias, and headaches.
The patients need to be monitored for blood lipids and liver enzymes especially closely. It has an X category for pregnancy.
Isotretinoin, generally combined with prednisone, is the approved therapy for severe acne conglobata.
The recommended dosage of isotretinoin is 0. Gollnick et al. Their study involved 85 patients with nodular papulopustular acne or acne conglobata who were treated for 6 months. The doses of isotretinoin were 0.
Overall, oral isotretinoin was more effective than the combined treatment.
The local side effects observed under the combination of AA and minocycline were significantly lower than that seen with isotretinoin 36.