Active Ingredients: Isotretinoin
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The only pitfall is it is longer than 10 months duration of treatment period. The low frequency of adverse side-effects in this study, suggest that most side effects of the drug, are dose dependent; and the most serious side effects of the drug can be reduced significantly by using lower doses.
Hence, we recommend this low dose therapy for treatment of moderate to severe scar prone acne. A large, prospective randomized comparative study is needed to establish the definitive response and tolerance of this protocol.In no patient was the treatment discontinued due to the abnormality in was detected. In only twenty patients, slight elevation of liver enzymes and serum lipids laboratory values.
Footnotes Conflict of Interest: None declared. Prevalence of facial acne vulgaris in late adolescence and in adults.
Br Med J. Oral isotretinoin is as effective as a combination of oral isotretinoin and topical anti-acne agents in nodulocystic acne. Indian J Dermatol Venereol Leprol.
Roaccutane treatment guidelines: Results of an international survey. Isotretinoin versus placebo in the treatment of cystic acne. A randomized double-blind study. J Am Acad Dermatol.
A review of the European Directive for prescribing systemic isotretinoin for acne vulgaris. J Eur Acad Dermatol Venereol.
Isotretinoin therapy for acne: Results of a multicenter dose-response study. Brelsford M, Beute TC.
Preventing and managing the side effects of isotretinoin. Semin Cutan Med Surg.
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